PLGA-Fluorescein (PLGA-FITC), MW 5K is a medium-molecular-weight fluorescein-terminated fluorescent biodegradable PLGA copolymer widely used for biological tracing, nanoparticle imaging, and medium-term drug delivery visualization. Featuring standard FITC fluorescent labeling and tunable PLGA ratios, this polymer delivers bright, stable green fluorescence with excellent biocompatibility, ideal for in vitro and in vivo real-time visual monitoring of biodegradable carrier behavior and distribution.
Basic Specifications
Alternative Name: PLGA-Fluorescein, PLGA-FITC
Lactide Ratio: 50:50, 65:35, 75:25, 85:15, Custom synthesis
Fluorescent Label: Fluorescein (FITC)
Excitation Wavelength: ~495 nm
Emission Wavelength: ~519 nm
Molecular Weight: 5K, Custom
Appearance: Yellow to yellow-green solid
Key Features and Benefits
Stable FITC Fluorescent Labeling: Terminal fluorescein (FITC) functionalization provides bright green fluorescence with standard ~495 nm excitation and ~519 nm emission peaks. It delivers low background interference and high-sensitivity optical signals, enabling direct real-time visualization and quantitative detection without additional staining.
Multi-Ratio & Custom Synthesis Support: Covers mainstream 50:50, 65:35, 75:25, 85:15 lactide-glycolide ratios and full custom synthesis services. Precise ratio adjustment flexibly regulates polymer hydrophilicity, degradation rate and particle morphology to match diverse medium-term sustained-release and biological imaging scenarios.
Balanced 5K Medium Molecular Weight Performance: Standard 5K molecular weight achieves an optimal balance of excellent organic solubility, moderate structural stability and steady degradation speed. It avoids rapid burst release of low-MW polymers and overly slow degradation of ultra-high-MW grades, perfectly suited for routine medium-term fluorescent formulation research.
Superior Biocompatibility & Biodegradability: Fully biodegradable under physiological conditions, gradually hydrolyzing into non-toxic lactic acid and glycolic acid. The material exhibits excellent biosafety, supporting repeated in vitro testing and reliable in vivo biological tracing applications.
Consistent Fluorescence Stability: Reliable terminal FITC modification effectively prevents fluorophore shedding and fluorescence quenching during particle preparation, storage and degradation, ensuring stable and repeatable fluorescent imaging results.
Applications
Real-Time Fluorescent Particle Tracing: Widely used for visual tracking and distribution analysis of PLGA nanoparticles and microspheres in cell and animal models, supporting intuitive carrier behavior observation.
Medium-Term Sustained Drug Delivery Imaging: Enables continuous visual monitoring of drug carrier degradation, drug release kinetics, in vivo accumulation and metabolic behavior for medium-cycle sustained-release formulation development.
Biomedical Fluorescent Labeling & Detection: Serves as a self-fluorescent polymer matrix for biodegradable material labeling, biological distribution evaluation and high-throughput optical detection experiments.
Formulation Stability & Mechanism Research: Facilitates intuitive assessment of nanoparticle stability, cellular uptake efficiency and sustained delivery performance for advanced drug delivery system research.
Storage and Handling
Storage: Store at –20 °C in a sealed, dry, light-proof and moisture-proof container to protect FITC fluorescence activity and polymer integrity.
Handling: Avoid strong light irradiation, repeated freeze-thaw cycles and high-temperature environments to prevent fluorescence quenching and premature polymer hydrolysis.
PLGA-Fluorescein (PLGA-FITC), MW 5K integrates balanced medium-molecular-weight degradability, multi-ratio customizable formulation and stable FITC green fluorescence, serving as a universal fluorescent tracing polymer for medium-term drug delivery imaging, nanoparticle tracking and routine biomedical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.