PLGA Cy5 Capped, MW 20K is an ultra-high-molecular-weight, Cy5-terminated fluorescent biodegradable PLGA copolymer with superior deep-red tissue penetration and ultra-low background fluorescence. Optimized for ultra-long-cycle in vivo tracing and multi-stage sustained drug delivery imaging, it supports customizable molecular weight and full-spectrum PLGA ratios to meet high-standard long-term biomedical material and formulation research needs.
Basic Specifications
Alternative Name: Cyanine 5-PLGA, Cy5-PLGA
PLGA Composition: 50:50, 65:35, 75:25, 85:15, Custom
Molecular Weight: 20K, Custom
Appearance: Blue to dark blue or purple solid
Key Features and Benefits
Cy5 Fluorescent Capped: Terminal Cy5 deep-red fluorophore modification delivers outstanding deep tissue penetration and minimal biological background noise. It enables high-sensitivity, ultra-long-term real-time fluorescence tracking and quantitative analysis without extra staining, perfectly suitable for deep-tissue imaging and multi-month in vivo long-cycle monitoring.
Versatile PLGA Ratio Options: Supports standard 50:50, 65:35, 75:25, 85:15 and fully customized lactide-glycolide ratios. Accurate ratio tuning flexibly adjusts polymer hydrophobicity, mechanical toughness and ultra-long degradation kinetics, adapting to diverse long-acting sustained-release formulation scenarios.
Customizable Ultra-High Molecular Weight: Standard 20K ultra-high molecular weight forms dense polymer chain entanglement, providing exceptional structural rigidity, superior particle stability and anti-deformation performance compared to low, medium and conventional high-MW PLGA. Custom molecular weight service enables personalized customization for ultra-long-cycle biomedical research.
Excellent Biocompatibility & Biodegradability: Features excellent biosafety and physiological compatibility, gradually and mildly hydrolyzing into non-toxic endogenous lactic acid and glycolic acid. No local inflammation or toxic residue, fully compliant with long-term in vivo implantation and prolonged biological tracing requirements.
Ultra-Stable Long-Term Fluorescence Performance: Precise terminal capping structure effectively avoids fluorophore shedding, migration and fluorescence quenching. It maintains consistent high-sensitivity fluorescent signals throughout ultra-long-term particle circulation, storage and slow polymer degradation.
Applications
Ultra-Long-Term Deep-Tissue Tracing: Specially designed for multi-month in vitro and in vivo tracking of PLGA nanoparticles and microspheres, supporting long-term tissue distribution, retention and metabolic behavior analysis.
Long-Cycle Sustained Drug Delivery Imaging: Enables visual monitoring of ultra-slow carrier degradation, long-term in vivo accumulation and sustained drug release kinetics for long-acting controlled-release drug formulation development.
Prolonged Biomedical Fluorescent Labeling: Acts as a high-rigidity self-fluorescent polymer matrix for long-term degradable scaffold labeling, implantable biomaterial imaging and persistent biological distribution evaluation.
High-Rigidity Custom Formulation Research: Combines ultra-high molecular weight stability and adjustable PLGA ratios to support the development of high-durability, long-acting targeted drug delivery systems and advanced functional biomaterials.
Storage and Handling
Storage: Store at –20 °C in a sealed, dry, light-proof and moisture-proof container.
Handling: Avoid strong light exposure, repeated freeze-thaw cycles and high-temperature environments to prevent fluorescence quenching and premature polymer hydrolysis, ensuring long-term sample stability and complete fluorescent activity.
PLGA Cy5 Capped, MW 20K integrates ultra-high structural stability, tunable ultra-long-cycle degradability and high-penetration Cy5 deep-red fluorescence, uniquely engineered for ultra-long-term deep-tissue biological tracing, long-cycle sustained drug delivery imaging and high-durability customized biomedical material research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.