8-Arm PLGA-Mal, MW 20K

Polymer Composition: 8-Arm Poly(lactic-co-glycolic acid)-Maleimide

8-Arm PLGA-Mal, MW 20K is an eight-arm star-shaped biodegradable polyester functionalized with maleimide groups at each arm terminus. Constructed on a central polyol core, its multi-branched structure delivers a higher density of reactive sites compared with linear PLGA. The material exhibits excellent biocompatibility and tunable degradation performance. Terminal maleimide groups enable highly selective thiol-maleimide click chemistry under mild aqueous environments, facilitating efficient conjugation with cysteine-bearing peptides, proteins and thiol-modified biomolecules. It is widely utilized in targeted nanoparticle synthesis, bioligand grafting, stimuli-responsive drug delivery and biomaterial surface modification research.