Azide-Polysarcosine-200 is an azide-functionalized hydrophilic polypeptoid with approximately 200 sarcosine repeat units. It combines a long polysarcosine chain with terminal azide functionality specifically for click chemistry, bioconjugation, surface modification, and biomaterial research.
Key Features and Benefits
- Azide-Functionalized Polysarcosine: Combines a hydrophilic polysarcosine backbone with a terminal azide group for selective functionalization.
- 200 Repeat Units: Provides approximately 200 sarcosine units for applications requiring an extended hydrophilic polymer chain.
- Azide Functionality: The terminal –N3 group provides a reactive site specifically for compatible click chemistry reactions.
- Click Chemistry Platform: Supports CuAAC coupling with terminal alkyne-containing molecules.
- Copper-Free Conjugation: Supports SPAAC reactions with compatible strained cyclooctynes, including DBCO and BCN groups.
- High Hydrophilicity: The polysarcosine backbone specifically provides strong hydrophilic character and supports aqueous compatibility.
- Low Nonspecific Interactions: Polysarcosine can help reduce nonspecific protein interactions in suitable polymer and surface systems.
- PEG Alternative: Provides a non-PEG hydrophilic platform specifically for functional polymer design, conjugation, and surface engineering.
Applications
- Click Chemistry: Supports selective azide-alkyne coupling for polymer modification and conjugation.
- Copper-Free Click Chemistry: Enables SPAAC conjugation with compatible DBCO-, BCN-, and other cyclooctyne-functionalized molecules.
- Bioconjugation: Supports attachment of compatible peptides, proteins, ligands, and other functional molecules.
- Polymer Functionalization: Enables incorporation of polysarcosine into block copolymers and other functional polymer architectures.
- Nanoparticle Functionalization: Supports click-mediated modification of compatible nanoparticles and polymeric systems.
- Surface Modification: Enables attachment of hydrophilic polysarcosine chains to suitably functionalized surfaces.
- Drug Delivery: Supports development of functional hydrophilic polymer systems for drug-delivery research.
- Biomaterial Research: Supports development of low-fouling surfaces, polymer conjugates, nanoparticles, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
Azide-Polysarcosine200 combines an extended hydrophilic polysarcosine chain with terminal azide functionality and specifically supports click chemistry, bioconjugation, surface modification, nanoparticle functionalization, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
