Azide-Poly(L-Aspartic Acid) (N3-pAsp), MW 14K is an azide-functionalized, hydrophilic poly(amino acid). It combines a poly(L-aspartic acid) backbone with terminal azide functionality specifically for click chemistry, bioconjugation, and biomaterial research.
Key Features and Benefits
- Azide-Functionalized Polymer: Combines hydrophilic poly(L-aspartic acid) with a terminal azide group for selective chemical modification.
- MW 14K: Provides an intermediate-molecular-weight polymer backbone specifically for conjugation, material development, and functional polymer research.
- Terminal Azide: Provides a reactive handle for copper-catalyzed and strain-promoted azide-alkyne click chemistry.
- Click Chemistry: Supports CuAAC with terminal alkynes and SPAAC with compatible strained cyclooctynes such as DBCO or BCN.
- Hydrophilic Polymer Backbone: Poly(L-aspartic acid) provides multiple carboxyl groups that specifically support hydrophilicity and aqueous compatibility.
- Carboxyl-Rich Structure: Pendant carboxyl groups provide additional sites for chemical modification after suitable activation.
- Biodegradable Poly(amino acid): The poly(L-aspartic acid) backbone specifically provides a biodegradable platform for biomaterial and delivery-system research.
- Multifunctional Polymer Platform: Combines terminal azide functionality with multiple pendant carboxyl groups for versatile polymer modification.
Applications
- Click Chemistry: Supports CuAAC and SPAAC reactions with compatible alkyne-functionalized molecules and materials.
- Bioconjugation: Enables click-based attachment of peptides, proteins, probes, ligands, and other compatible components.
- Polymer Functionalization: Provides terminal azide and pendant carboxyl groups for selective polymer modification strategies.
- Nanoparticle Functionalization: Supports development and surface modification of functional nanoparticle systems.
- Drug Delivery: Supports development of functional polymer conjugates and delivery systems for research applications.
- Surface Modification: Enables click-based attachment to compatible alkyne-functionalized surfaces and materials.
- Biomaterial Development: Supports preparation of functional hydrophilic polymers, conjugates, coatings, and related biomaterials.
- Material Research: Provides a versatile poly(amino acid) platform for functional polymer and conjugation studies.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
N₃-Poly(L-Asp), MW 14K combines a hydrophilic poly(amino acid) backbone with terminal azide functionality and specifically supports click chemistry, bioconjugation, polymer modification, drug-delivery research, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.