DBCO-NH-PEG2-NHS ester
This product is a heterobifunctional PEG2 linker featuring a dibenzocyclooctyne (DBCO) group for copper-free click chemistry and an NHS ester for rapid amine coupling. The PEG2 spacer specifically provides hydrophilicity and short flexibility, making it a powerful reagent for bioconjugation, probe design, and drug delivery.
Key Features and Benefits:
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DBCO Group: Enables strain-promoted azide–alkyne cycloaddition (SPAAC) without copper catalysts.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG2 Spacer: Provides solubility, reduced steric hindrance, and compact spacing.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
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Dual Reactivity: Combines click-ready and amine-reactive handles for multifunctional use.
Applications:
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Click Chemistry: Copper-free ligation with azides for in vitro and in vivo applications.
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Bioconjugation: Enables dual-functional modification of proteins, peptides, and biomolecules.
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Drug Delivery: PEGylated linker enhances solubility, stability, and targeting.
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Surface Functionalization: Functionalizes nanoparticles, polymers, and biosensors.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain NHS and DBCO integrity.
This product combines fast, copper-free click chemistry with efficient amine reactivity in a short PEG spacer, making it an especially excellent choice for dual conjugation and advanced bioconjugation applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
