OPSS-Poly(L-Lysine), MW 3.3K is an OPSS-functionalized cationic poly(amino acid) based on poly(L-lysine). It combines an amine-rich PLL chain with thiol-reactive OPSS functionality specifically for conjugation, surface modification, and biomaterial research.
Key Features and Benefits
- Cationic Poly(amino acid): Poly(L-lysine) provides positively charged primary amine groups for electrostatic interactions and functionalization.
- MW 3.3K: The low molecular weight PLL chain specifically provides a compact cationic polymer structure with reactive functionality.
- Terminal OPSS Group: Provides orthopyridyl disulfide functionality specifically for selective reaction with compatible thiol-containing molecules.
- Thiol-Reactive Chemistry: OPSS reacts with sulfhydryl groups through disulfide exchange to form disulfide-linked conjugates.
- Disulfide Conjugation: The resulting disulfide linkage can undergo cleavage under suitable reducing conditions.
- Primary Amine-Rich Structure: Lysine side chains specifically provide multiple primary amines for electrostatic interactions and additional functionalization.
- Bioconjugation Platform: Supports conjugation with compatible thiol-containing peptides, proteins, ligands, polymers, and other molecules.
Applications
- Thiol Conjugation: OPSS functionality supports selective coupling with compatible sulfhydryl-containing molecules.
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, ligands, and other functional compounds.
- Reversible Conjugation: Disulfide linkages support research involving reduction-responsive or cleavable conjugates.
- Polymer Functionalization: Provides thiol-reactive functionality for preparing modified polymer conjugates and hybrid materials.
- Nanoparticle Functionalization: Supports modification of compatible nanoparticle surfaces using thiol-disulfide exchange chemistry.
- Surface Modification: Enables attachment of OPSS-functionalized PLL to compatible thiol-containing surfaces and materials.
- Drug Delivery: Supports development of functional polymer conjugates and delivery systems for research applications.
- Biomaterial Research: Supports development of cationic polymer conjugates, functional surfaces, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
OPSS-Poly(L-Lysine), MW 3.3K combines a compact cationic PLL chain with thiol-reactive OPSS functionality and specifically supports thiol conjugation, reversible disulfide coupling, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.