OPSS-Poly(L-Lysine), MW 8.2K is an OPSS-functionalized cationic poly(amino acid) based on poly(L-lysine). It combines an amine-rich PLL chain with thiol-reactive OPSS functionality specifically for conjugation, surface modification, and biomaterial research.
Key Features and Benefits
- Cationic Poly(amino acid): Poly(L-lysine) provides multiple cationic side-chain amino groups for electrostatic interactions with anionic molecules and materials.
- MW 8.2K: Provides a moderate molecular weight polymer specifically for conjugation, surface modification, and functional material development.
- Terminal OPSS Group: Provides an orthopyridyl disulfide functionality specifically for selective reaction with compatible thiol-containing compounds.
- Thiol-Reactive Chemistry: OPSS reacts with sulfhydryl groups through disulfide exchange to form a new disulfide linkage.
- Disulfide Conjugation: The resulting disulfide bond provides a cleavable linkage under suitable reducing conditions.
- Primary Amine-Rich Structure: Lysine side chains specifically provide multiple amino groups for electrostatic interactions and further chemical functionalization.
- Bioconjugation Platform: Supports attachment of thiol-containing peptides, proteins, ligands, and other functional molecules.
Applications
- Thiol Conjugation: Supports selective coupling with compatible sulfhydryl-containing molecules through disulfide exchange.
- Bioconjugation: Enables attachment of thiol-containing peptides, proteins, ligands, and other biomolecules.
- Reversible Conjugation: Supports research involving disulfide linkages that can cleave under suitable reducing conditions.
- Polymer Functionalization: Provides OPSS functionality for incorporating poly(L-lysine) into compatible functional polymer systems.
- Nanoparticle Functionalization: Provides a thiol-reactive handle for modifying compatible nanoparticles and polymer assemblies.
- Surface Modification: Supports thiol-mediated attachment to compatible functional surfaces and materials.
- Drug Delivery: Supports development of functional cationic polymers for drug-delivery and formulation research.
- Biomaterial Research: Supports development of functional polymer conjugates, coatings, complexes, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
OPSS-Poly(L-Lysine), MW 8.2K combines an amine-rich poly(L-lysine) chain with thiol-reactive OPSS functionality and specifically supports disulfide conjugation, bioconjugation, surface functionalization, and functional biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.