Hyaluronic Acid Thiol (HA-SH), MW 10K is a thiol-functionalized derivative of low molecular weight hyaluronic acid and specifically combines a hydrophilic HA backbone with reactive thiol groups for crosslinking, conjugation, polymer functionalization, and biomaterial research.
Key Features and Benefits
- Hyaluronic Acid Backbone: Features a hydrophilic polysaccharide backbone based on hyaluronic acid.
- MW 10K: Provides a low molecular weight HA platform specifically for crosslinking, conjugation, and functional biomaterial studies.
- Thiol Functionality: Reactive thiol groups specifically provide sites for crosslinking and conjugation with compatible thiol-reactive compounds.
- Thiol-Reactive Chemistry: Supports reactions with maleimides, vinyl sulfones, and other compatible thiol-reactive functional groups.
- Crosslinking Capability: Thiol groups enable chemical crosslinking for preparing HA-based polymer networks and hydrogels.
- Hydrophilic Character: The HA backbone specifically provides strong hydrophilic character for aqueous polymer and biomaterial systems.
- Anionic Character: Hyaluronic acid specifically carries negative charge under suitable pH conditions and can interact with compatible cationic materials.
- Functional Biomaterial Platform: Combines 10K HA with reactive thiol groups for material modification, conjugation, and network formation.
Applications
- Hydrogel Formation: Supports preparation of crosslinked HA hydrogels using compatible thiol-reactive crosslinkers.
- Polymer Crosslinking: Enables formation of functional polymer networks through thiol-based chemistry.
- Bioconjugation: Thiol groups provide reactive sites for conjugation with compatible maleimide and other thiol-reactive molecules.
- Polymer Functionalization: Enables attachment of compatible ligands, polymers, and functional components through thiol chemistry.
- Surface Modification: Supports thiol-mediated modification of compatible surfaces and materials.
- Nanoparticle Functionalization: Enables incorporation or conjugation of HA-SH in compatible nanoparticle systems.
- Conjugate Development: Supports preparation of functional HA conjugates using thiol-selective chemistry.
- Biomaterial Research: Supports development of functional HA polymers, conjugates, networks, nanoparticles, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize prolonged exposure to air to reduce oxidation of thiol groups.
Hyaluronic Acid Thiol (HA-SH), MW 10K combines low molecular weight hyaluronic acid with reactive thiol functionality and specifically supports crosslinking, bioconjugation, polymer functionalization, nanoparticle modification, and biomaterial research.
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