DBCO-Biotin
This product is a heterobifunctional reagent combining a dibenzocyclooctyne (DBCO) group with biotin. It specifically enables copper-free click chemistry with azides and provides strong streptavidin/avidin affinity for capture, detection, and imaging.
Key Features and Benefits
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Dual Functionality: DBCO enables copper-free click with azides; biotin provides streptavidin binding.
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Copper-Free Click Chemistry: Safe for live-cell and in vivo use, avoiding cytotoxic catalysts.
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High Specificity: Rapid, selective conjugation under physiological conditions.
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Affinity Tag: Biotin allows pull-down, detection, and immobilization assays.
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High Purity: Ensures reproducibility in bioconjugation and diagnostic workflows.
Applications
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Affinity Capture: Binds azide-modified biomolecules via streptavidin/avidin systems.
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Diagnostics: Supports detection platforms and assay development.
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Bioorthogonal Labeling: Enables imaging and tracking in cells and tissues.
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Proteomics: Facilitates pull-down assays and biomolecule immobilization.
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Drug Delivery: Used in targeted delivery studies and conjugate design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, dry, and light-protected container.
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Handling: Use anhydrous solvents such as DMSO; avoid prolonged exposure to moisture.
This product integrates a DBCO click handle with biotin affinity, specifically providing efficient copper-free conjugation and reliable capture for bioconjugation and diagnostic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
