Description
1,2-Bis(2-azidoethoxy)ethane (Azide-PEG2-Azide, N3-PEG2-N3, N3-PEG-N3) is a linear bifunctional PEG crosslinker bearing two terminal azide groups. It enables efficient copper-catalyzed or copper-free click chemistry reactions with alkynes and DBCO derivatives, and is widely used for bioconjugation, PEGylation, molecular crosslinking, and the construction of multifunctional biomolecular complexes.
Key Features
- Homobifunctional PEG derivative with two reactive azide groups for dual-site conjugation.
- Short hydrophilic PEG2 spacer improves water solubility and reduces steric hindrance.
- Reacts efficiently with alkynes, DBCO, and strained alkynes via bioorthogonal click chemistry.
- Enables stable covalent crosslinking between biomolecules, labeling probes, and functional materials.
- Suitable for biocompatible modification under mild reaction conditions.
Applications
- Bioconjugation and PEGylation of proteins, peptides, antibodies, and drug molecules.
- Crosslinking and assembly of multifunctional nanoparticles and drug delivery systems.
- Construction of antibody-drug conjugates (ADCs) and targeted therapeutic complexes.
- Biomolecular labeling, imaging probe development, and surface functionalization.
- Synthesis of hydrogels, polymeric materials, and bioorthogonal chemical probes.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
