Propargyl-PEG4-amine
This product is a heterobifunctional PEG linker containing a terminal propargyl (alkyne) group and a primary amine, separated by a PEG4 spacer. The alkyne enables copper-catalyzed or copper-free click chemistry with azides, while the amine allows conjugation to activated esters or carboxylic acids. The PEG4 spacer specifically enhances solubility and flexibility, reducing steric hindrance during coupling.
Key Features and Benefits
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Propargyl Group: Supports CuAAC or SPAAC click reactions with azides for selective ligation.
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Primary Amine: Enables amide bond formation with activated carboxyls or NHS esters.
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PEG4 Spacer: Improves solubility and reduces steric interference in bioconjugation workflows.
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Bifunctional Design: Provides orthogonal handles for sequential or multifunctional conjugations.
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High Purity: Produced to ≥95% purity for reproducible results.
Applications
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Bioconjugation: Couples azide-functionalized probes, biomolecules, or drugs via click chemistry.
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Polymer and Surface Modification: Introduces dual functionality into polymers or nanoparticles.
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Probe Development: Builds multifunctional imaging and diagnostic probes.
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Drug Delivery: Serves as a versatile linker for PEGylated therapeutics.
Storage and Handling
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Storage: Store at –20 °C in a sealed container, away from light and moisture.
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Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product combines orthogonal alkyne and amine functionalities with a solubilizing PEG4 spacer, making it an especially powerful tool for click chemistry, amide coupling, and advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
