Mal-PEG2-tris-PEG4-alkyne is a tri-functional PEG linker designed for advanced bioconjugation and chemical biology applications. It features a maleimide group for thiol-specific conjugation and three terminal alkyne groups for copper-catalyzed azide-alkyne cycloaddition (CuAAC). The PEG2 and PEG4 spacers enhance solubility, flexibility, and reduce steric hindrance, making it suitable for a wide range of biological and chemical applications.
Key Features
- Functional Groups:
- Maleimide: Reacts with thiol groups (-SH) to form stable thioether bonds.
- Tris-Alkyne: Provides three reactive sites for CuAAC (“click chemistry”) with azides.
- Enhanced PEG Linkers:
- PEG2 and PEG4 spacers improve solubility and flexibility.
- Minimize steric interference for efficient conjugation.
- Biocompatibility:
- Non-toxic and ideal for use in biological systems.
Applications
- Bioconjugation: Links peptides, proteins, or other biomolecules via thiol and alkyne chemistry.
- Drug Delivery: Serves as a linker to enhance the stability and solubility of drug conjugates.
- Nanotechnology: Functionalizes nanoparticles, biosensors, and surfaces for precise labeling and modification.
- Chemical Biology: Enables multi-site labeling and complex molecule assembly using CuAAC.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
