Methyltetrazine-PEG4-Aldehyde is a heterobifunctional linker featuring a methyltetrazine group for bioorthogonal click chemistry and an aldehyde group for covalent attachment to amine-containing molecules via Schiff base formation or reductive amination. The PEG4 spacer enhances solubility and reduces steric hindrance for efficient conjugation.
Key Features
- Bioorthogonal Methyltetrazine
Reacts rapidly and selectively with strained alkenes (e.g., trans-cyclooctene) via IEDDA reactions. - Reactive Aldehyde Group
Forms covalent bonds with primary amines through Schiff base formation or reductive amination. - Hydrophilic PEG4 Spacer
Improves solubility in aqueous systems and minimizes steric interference.
Applications
- Bioconjugation
Enables efficient attachment of biomolecules, fluorophores, or polymers. - Drug Delivery
Useful in creating targeted drug conjugates with aldehyde-reactive payloads. - Material Functionalization
Facilitates surface modification of particles, hydrogels, and other materials. - Molecular Probes
Ideal for designing probes requiring dual reactivity.
Advantages
Methyltetrazine-PEG4-Aldehyde offers dual functionality for precise, versatile conjugation in bioconjugation, imaging, and therapeutic research applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
