Methyltetrazine-PEG4-SS-NHS is a cleavable, heterobifunctional linker featuring methyltetrazine for bioorthogonal click chemistry, a disulfide bond for controlled cleavage under reducing conditions, and an NHS ester for efficient amine-specific conjugation. The PEG4 spacer enhances solubility and reduces steric hindrance.
Key Features
- Methyltetrazine Group
Enables fast, selective bioorthogonal IEDDA reactions with strained alkenes (e.g., trans-cyclooctene). - Cleavable Disulfide Bond
Allows controlled molecule release in reducing environments. - NHS Ester Group
Reacts efficiently with primary amines to form stable amide bonds. - PEG4 Spacer
Improves water solubility and minimizes steric hindrance.
Applications
- Bioconjugation
Enables precise labeling of biomolecules with dual functionality. - Drug Delivery
Facilitates the creation of cleavable drug conjugates for targeted release. - Molecular Probes
Ideal for designing functional imaging or diagnostic agents. - Material Functionalization
Suitable for modifying surfaces, nanoparticles, or polymers.
Short Description
Methyltetrazine-PEG4-SS-NHS is a cleavable linker with methyltetrazine for IEDDA reactions, a disulfide bond for controlled release, and an NHS ester for amine conjugation. Ideal for bioconjugation, drug delivery, and imaging applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
