Methyltetrazine-PEG4-SS-PEG4-Methyltetrazine
This molecule is a cleavable, homobifunctional linker designed for bioconjugation and controlled release applications. It features two methyltetrazine groups connected by a PEG4 spacer and a disulfide bond.
Key Features
- Cleavable Disulfide Bond
Allows controlled cleavage under reducing conditions, enabling the release of conjugated molecules. - Hydrophilic PEG4 Spacers
Improves water solubility, reduces steric hindrance, and enhances flexibility during conjugation. - Methyltetrazine Functional Groups
Enables rapid and highly selective bioorthogonal click chemistry via inverse electron demand Diels-Alder (IEDDA) reactions with strained alkenes (e.g., TCO).
Applications
- Bioconjugation
Ideal for attaching biomolecules, such as in antibody-drug conjugates or targeted therapeutics. - Drug Delivery
Enables the creation of systems where therapeutic agents are released in response to intracellular reducing environments. - Molecular Imaging
Facilitates the labeling of imaging probes for visualizing biological processes. - Material Science
Useful in creating functional polymers and hydrogels for biomedical applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.