Methyltetrazine-PEG5-NHS is a heterobifunctional linker featuring a tetrazine for bioorthogonal IEDDA reactions and an active ester for amine-specific conjugation. The PEG5 spacer enhances solubility and minimizes steric hindrance for efficient reactions.
Key Features
- Methyltetrazine Group
Enables fast and selective reactions with strained alkenes (e.g., trans-cyclooctene). - NHS Ester
Reacts efficiently with primary amines, forming stable amide bonds. - PEG5 Spacer
Enhances solubility and flexibility for improved conjugation efficiency.
Applications
- Bioconjugation
Ideal for amine-specific labeling of proteins, peptides, or other biomolecules. - Drug Delivery
Facilitates the development of targeted therapeutic conjugates. - Molecular Imaging
Enables the attachment of imaging agents for diagnostics. - Surface Modification
Useful for functionalizing nanoparticles, hydrogels, and polymers.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
