5-Vinyl-uridine (CAS: 55520-64-4)
5-Vinyl-uridine is a uridine derivative with a vinyl (-CH=CH₂) group, enabling its incorporation into RNA for studying RNA synthesis and dynamics.
Features:
- Molecular Formula: C₁₁H₁₄N₂O₆
- Molecular Weight: 270.24 g/mol
- Functional Group: Vinyl (-CH=CH₂)
- Purity: ≥98% (HPLC)
- Physical State: White to off-white solid
- Solubility: Soluble in DMSO and methanol
Applications:
- RNA Metabolic Labeling:
- Incorporated into newly synthesized RNA, replacing uridine.
- Enables RNA transcription monitoring in cells and organisms.
- Click Chemistry Detection:
- The vinyl group reacts with tetrazines using inverse electron-demand Diels-Alder (IEDDA) chemistry.
- Allows for fluorescence-based RNA detection via microscopy or flow cytometry.
- Alternative to 5-Ethynyl-uridine (EU):
- Offers a copper-free click chemistry approach, avoiding cytotoxicity linked to copper catalysts.
Storage and Handling:
- Storage Temperature: -20°C
- Shipping Conditions: Ambient temperature
- Shelf Life: 12 months after delivery
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
