Thalidomide-O-PEG2-azide is a compound combining thalidomide, a PEG2 spacer, and an azide group, designed for targeted protein degradation and bioconjugation.
Key Features:
- Thalidomide Moiety: Binds to the cereblon (CRBN) E3 ubiquitin ligase for protein degradation.
- PEG2 Spacer: Enhances solubility and flexibility.
- Azide Group: Enables click chemistry for conjugation with alkyne-functionalized molecules.
Applications:
- PROTAC Development: Enables selective protein degradation by recruiting CRBN E3 ligase.
- Bioconjugation: Attaches thalidomide to biomolecules for studying protein functions.
- Drug Discovery: Supports the design of novel therapeutic agents.
Thalidomide-PEG2-azide is a versatile tool for advancing chemical biology and targeted therapy research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
