N-ethyl-N’-(3-dimethylaminopropyl)carbodiimide, EDC
- CAS Number: 25952-53-8
- Formula: C8H17N3 (base), often used as EDC-HCl (hydrochloride salt).
- Molecular Weight: 155.24 g/mol (base), 191.70 g/mol (HCl).
- Appearance: White/off-white powder.
- Solubility: Water, DMSO, ethanol.
Key Applications:
- Amide Bond Formation
- Activates carboxylic acids to react with amines (used in peptide synthesis, protein labeling).
- Often paired with NHS or sulfo-NHS for higher efficiency.
- Chemical Synthesis:
- Facilitates ester and amide formation.
- Biomaterial Functionalization:
- Used in drug delivery, surface modification, and immunoassays.
Handling:
- Storage: 2–8°C, dry, protected from moisture.
- Precautions: Use gloves and work in a fume hood; EDC is an irritant.
Reaction Summary:
- Forms reactive intermediates (O-acylisourea) from carboxyl groups.
- Reacts with amines to create stable amide bonds, though susceptible to hydrolysis.
Clear and efficient for bioconjugation and synthetic chemistry needs. Let me know if you need further details!
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