Methylcyclopropene-PFP (Methylcyclopropene PFP Ester): Overview and Applications
Product Summary
A bioconjugation reagent that combines a methylcyclopropene tag for bioorthogonal click chemistry and a pentafluorophenyl (PFP) ester for effective amine coupling. This carbamate-linked tag integrates into cellular pathways without disrupting function, enabling targeted labeling and tracking through its high reactivity in inverse-electron-demand Diels-Alder (DAinv) reactions.
Applications
- Antibody-Drug Conjugates (ADCs)
- Facilitates stable drug attachment to antibodies through selective amine coupling, crucial for targeted therapy applications.
- Biomolecule Labeling
- Allows for selective labeling of proteins, peptides, or other amine-containing biomolecules for detection and tracking.
- Surface Modification
- Useful in adding bioactive molecules to surfaces, enhancing biosensor sensitivity and diagnostic tool functionality.
- Targeted Drug Delivery
- Supports targeted drug delivery by enabling precise biomolecule conjugation, increasing therapeutic efficacy.
- Click Chemistry Applications
- Provides efficient DAinv click chemistry, ideal for bioconjugation in complex cellular environments.
Reference:
Rapid Labeling of Metabolically Engineered Cell-Surface Glycoconjugates with a Carbamate-Linked Cyclopropene Reporter, Anne-Katrin Spa.te, Holger Buskamp, Andrea Niederwieser, Verena F. Schart, Andreas Marx, and Valentin Wittmann Bioconjugate Chem. 2014, 25, 147-154
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
