4-Aminobutyl-DOTA-tris (t-butyl ester) (CAS: 1402393-59-2) is a protected derivative of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) featuring three tert-butyl ester groups and a 4-aminobutyl chain. The tert-butyl esters protect the carboxyl groups during synthesis, allowing for targeted modifications before deprotection. Once deprotected, it forms a strong chelator for metal ions, making it suitable for radiolabeling in PET, SPECT, and other diagnostic applications.
Key Features:
- Type: Protected DOTA derivative with tert-butyl esters
- Function: Precursor for DOTA-based chelators; protects carboxyl groups during synthesis
- Applications:
- Radiolabeling
- Diagnostic imaging
- Metal ion coordination
- Biomedical research
- Advantages: Facilitates easy modification, strong metal chelation after deprotection
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