Maleimido-mono-amide-DOTA-tris (t-Bu ester), CAS Number 1613382-10-7, is a chemical compound widely used for bioconjugation, particularly in radiolabeling and imaging studies. Here’s a quick overview:
Overview
- Full Name: Maleimido-mono-amide-DOTA-tris (tert-Butyl ester).
- CAS Number: 1613382-10-7.
- Chemical Formula: C31H50N5O8.
- Molecular Weight: 619.76 g/mol.
Key Applications
- Bioconjugation: The maleimide group reacts specifically with thiol groups (-SH), allowing for targeted attachment to cysteine residues in proteins or peptides.
- Radiolabeling: DOTA serves as a versatile chelator for metal ions such as Gadolinium (Gd) for MRI or Lutetium-177 (Lu-177) for cancer radiotherapy.
- Imaging: Often used in creating molecular imaging agents for PET, SPECT, and MRI applications.
Properties
- Maleimide Group: Highly reactive with thiols, making it ideal for site-specific protein modification.
- tert-Butyl Ester Protection: Ensures stability during synthesis, protecting DOTA’s carboxyl groups until deprotection is needed for metal chelation.
- Chelating Agent: DOTA binds tightly to metal ions, enhancing stability and functionality of labeled biomolecules.
Handling and Storage
- Storage: Keep in a dry, cool place away from light and moisture to maintain the integrity of reactive groups.
- Handling: Use protective equipment to prevent reactions with unintended thiol-containing compounds.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
