Azido-mono-amide-DOTA-tris(t-Bu ester), CAS Number 1402795-92-9, is a specialized bioconjugation compound commonly used in radiolabeling and molecular imaging. Here’s a concise overview:
Overview
- Full Name: Azido-mono-amide-DOTA-tris (tert-butyl ester).
- CAS Number: 1402795-92-9.
- Chemical Formula: C29H50N6O8.
- Molecular Weight: 610.76 g/mol.
Key Applications
- Bioconjugation: The azide group facilitates “click chemistry” reactions with alkyne-modified molecules, allowing easy attachment to a wide range of biomolecules.
- Radiolabeling: DOTA’s chelating ability binds to metal ions, such as Gallium-68 for PET imaging or Yttrium-90 for radiotherapy.
- Imaging: Useful in creating stable imaging agents for PET, SPECT, and MRI applications, enhancing diagnostic capabilities in biomedical research.
Properties
- Azide Group: Enables efficient click chemistry, a reliable method for linking biomolecules.
- tert-Butyl Ester Protection: Protects DOTA’s carboxyl groups during synthesis, maintaining stability until deprotection for metal chelation.
- Chelating Power: DOTA forms strong complexes with metal ions, ensuring stability of radiolabeled compounds.
Handling and Storage
- Storage: Keep in a cool, dry place, protected from light to maintain reactivity.
- Handling: Use standard protective equipment, as the azide group can be reactive with certain chemicals.
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