N-(PFP ester-PEG3)-N-bis(PEG3-azide)
This product is a multifunctional PEG linker combining a pentafluorophenyl (PFP) ester arm with two azide-terminated PEG3 chains. The PFP ester reacts efficiently with primary amines to form stable amide bonds, while the azides perform copper-catalyzed (CuAAC) or copper-free (SPAAC) click chemistry with alkynes. The PEG3 spacers provide solubility, flexibility, and reduced steric hindrance, making this reagent especially versatile for multifunctional conjugation strategies.
Key Features and Benefits
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PFP Ester Group: Couples efficiently with primary amines for stable amide bonds.
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Dual Azides: Enable CuAAC or SPAAC click chemistry with alkynes.
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PEG3 Spacers: Enhance solubility and accessibility.
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Trifunctional Design: Supports orthogonal and multifunctional conjugation strategies.
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High Purity: Produced to ≥95% purity for consistent results.
Applications
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Bioconjugation: Links amine-containing and alkyne-modified biomolecules.
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Protein and Antibody Labeling: Provides multifunctional handles for orthogonal modifications.
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Probe Development: Builds dual-click probes for imaging and diagnostics.
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Drug Delivery: Functions as a modular scaffold in therapeutic systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Prepare fresh solutions; PFP esters and azides are moisture-sensitive.
This product integrates amine-reactive PFP ester chemistry with dual azide handles in a PEG scaffold, specifically enabling highly versatile multifunctional conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
