Folate-PEG2 DBCO Amide
This product is a heterobifunctional PEG linker specifically with a folate moiety and a DBCO amide joined by a PEG2 spacer. It specifically enables folate receptor targeting and efficient copper-free SPAAC bioconjugation for therapeutic and diagnostic applications.
Key Features and Benefits
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Folate Moiety: Provides receptor-mediated targeting of folate-expressing cells.
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DBCO Group: Enables copper-free, bioorthogonal click chemistry with azides.
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PEG2 Spacer: Improves solubility and minimizes steric interference.
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Stable Amide Linkage: Ensures hydrolysis resistance and long-term stability.
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High Purity: Produced at ≥95% purity for reproducible research outcomes.
Applications
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Antibody–Drug Conjugates (ADCs): Supports folate receptor-targeted therapeutic design.
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Bioconjugation: Links proteins, peptides, or oligonucleotides to azide-functionalized molecules.
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Nanoparticle Modification: Functionalizes carriers for selective targeting and delivery.
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Imaging and Diagnostics: Conjugates imaging probes for cancer detection.
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Targeted Drug Delivery: Directs payloads to folate receptor-positive cells.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container, protected from light.
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Handling: Prepare fresh solutions; avoid repeated freeze–thaw cycles.
This product combines folate targeting with copper-free click chemistry in a compact PEG2 linker, especially ideal for precision bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
