Name: Exatecan
SKU: AP15197
Availability: InStock

Exatecan

$155.00 – $510.00

Exatecan CAS:171335-80-1 is an innovative camptothecin (CPT) analog that demonstrates powerful topoisomerase-I inhibitory and antitumor activities. Its unique structure makes it highly effective against P-glycoprotein (P-gp) mediated multi-drug resistant cells, overcoming a major challenge in cancer therapy. Several Exatecan derivative-based antibody-drug and peptide-drug conjugate payloads exhibit impressive therapeutic indices across a broad spectrum of solid tumors. As a result, Exatecan is paving the way for the development of more effective and targeted cancer treatments, offering new hope for patients battling resistant malignancies.

Unit

Price

Quantity

5 mg

$155

25 mg

$510

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Exatecan (CAS: 171335-80-1) is a potent topoisomerase I inhibitor used in cancer research. This camptothecin derivative blocks DNA replication in cancer cells by stabilizing the DNA-topoisomerase I complex, leading to cell death.

Key Information:

CAS Number: 171335-80-1
IUPAC Name: (S)-9-[(dimethylamino)methyl]-10-hydroxy-7-ethyl-4,7-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Molecular Formula: C22H19N3O5
Molecular Weight: 405.41 g/mol

Applications:

Cancer Research: Exatecan shows strong antitumor activity and is widely studied in developing Antibody-Drug Conjugates (ADCs) for targeted therapies.
Drug Development: Its cytotoxic effects make it a critical component in cancer treatments designed to target and destroy cancer cells.

Exatecan is particularly effective in targeted therapies, delivering high precision and minimizing damage to healthy tissue.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.