Biotin-Cystamine Hydrochloride, CAS 1346597-28-1, is a versatile biotin derivative used in biochemical research, protein labeling, and drug delivery studies. Its unique structure includes a biotin moiety linked to cystamine through a cleavable disulfide bond, making it ideal for reversible linkages in molecular experiments.
Key Features and Applications
- Structure and Properties
- Chemical Formula: C14H26N4O2S2·HCl
- Molecular Weight: 398.98 g/mol
- Contains a biotin tag and a disulfide bond sensitive to reducing agents.
- Applications
- Protein Labeling: Easily biotinylates proteins and peptides, enabling detection and purification due to strong biotin-avidin binding.
- Drug Delivery: Used in targeted delivery systems, releasing drugs under reducing conditions within cells.
- Bioconjugation: Creates reversible links between biomolecules, aiding in dynamic studies and protein modifications.
- Diagnostics and Research: Enhances assays by leveraging biotin-streptavidin interactions for detection and signal amplification.
- Mechanism of Action
- Biotin binds specifically to avidin or streptavidin, facilitating isolation and detection.
- The disulfide bond cleaves in reductive environments, allowing for controlled release of biotin or other linked molecules.
- Handling and Storage
- Store at -20°C in a dry, dark environment to maintain stability.
- Keep away from light and moisture to protect the disulfide bond.
Biotin-Cystamine Hydrochloride combines targeted interaction and controlled release, making it a key reagent in advanced biochemical and pharmaceutical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
