Azide-PEG4-Ms (CAS: 134179-43-4)
Overview:
Azide-PEG4-Ms is a multifunctional molecule with a polyethylene glycol (PEG4) chain, an azide group (-N3), and a mesyl (Ms) group. The azide group works well for bioorthogonal reactions, such as click chemistry with alkyne-containing molecules. In addition, the mesylate group acts as a leaving group in nucleophilic substitution, making it valuable for mesylation. Furthermore, the PEG4 spacer boosts solubility and flexibility. These combined features make Azide-PEG4-Ms ideal for bioconjugation, drug delivery, and other applications.
Key Features:
- Azide Group: Supports selective click chemistry for attaching biomolecules or therapeutic agents.
- Mesyl Group (Mesylate): Facilitates nucleophilic substitution and mesylation reactions.
- PEG4 Spacer: Increases solubility and minimizes steric hindrance.
Applications:
- Bioconjugation: Links proteins, peptides, or other biomolecules through click chemistry and mesylation.
- Drug Delivery: Attaches therapeutic agents to delivery systems, improving solubility and stability.
- Polymer Chemistry: Serves as a building block for synthesizing complex molecules, aided by the mesyl group’s role in substitution reactions.
In summary, Azide-PEG4-Ms is essential for mesylation, click chemistry, and drug delivery. Its flexibility, reactivity, and solubility make it valuable in biochemical and pharmaceutical applications.
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