Biotin-PEG8-DBCO contains three functional groups: biotin, PEG, and dibenzocyclooctyne (DBCO). The biotin group allows for specific binding to streptavidin or avidin, while the PEG chain provides water solubility and biocompatibility. The DBCO group enables the compound to undergo click chemistry with azide-modified molecules.
Biotin-PEG8-DBCO has been extensively utilized in the development of targeted drug delivery systems, imaging agents, and diagnostic tools. Its unique chemical properties allow for the specific and efficient conjugation of therapeutic agents, imaging probes, or biomolecules, to the biotin group via streptavidin or avidin. The resulting conjugates exhibit improved selectivity, efficacy, and reduced off-target effects, leading to enhanced therapeutic or diagnostic outcomes.
Biotin-PEG8-DBCO can be utilized as a surface modifier or bioorthogonal linker in various biomedical applications. For instance, it can be immobilized onto the surface of nanoparticles, liposomes, or medical devices, to improve biocompatibility, targeting, and controlled release.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
