Aminooxy-PEG2-TCO HCl Salt (in solution)
This product is a heterobifunctional PEG linker containing an aminooxy group, a PEG2 spacer, and a trans-cyclooctene (TCO). Supplied as an HCl salt in solution, it specifically enables oxime ligation and rapid bioorthogonal click chemistry with tetrazines.
Key Features and Benefits
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Aminooxy Group: Couples with aldehydes or ketones to form stable oxime bonds.
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TCO Group: Reacts rapidly with tetrazines via IEDDA click chemistry.
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PEG2 Spacer: Enhances solubility while maintaining compact length.
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Dual Reactivity: Combines carbonyl ligation with bioorthogonal click chemistry.
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Solution Form: Convenient HCl salt solution ensures stability and immediate use.
Applications
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Bioconjugation: Links carbonyl- and tetrazine-modified biomolecules.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Provides PEG scaffolds with orthogonal reactivity.
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Chemical Biology: Enables bioorthogonal labeling in live-cell environments.
Storage and Handling
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Storage: Store at –20 °C in sealed vials; protect from light and moisture.
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Handling: Supplied in solution; avoid repeated freeze–thaw cycles.
This product integrates oxime ligation and tetrazine click chemistry in a PEG2 scaffold, specifically delivered in a stable solution form for immediate use.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
