Aminooxy-PEG2-BCN (CAS: 2253965-14-7)
Description:
Aminooxy-PEG2-BCN is a versatile cross-linker used in bioconjugation and protein modification. It has an aminooxy group that reacts with aldehydes and ketones to form stable oxime linkages, and a BCN (bicyclo[6.1.0]non-4-yne) group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azides without requiring copper catalysts.
Key Features:
- Dual Reactivity: Contains aminooxy and BCN groups for flexible conjugation.
- PEG2 Spacer: Enhances solubility and flexibility, minimizing steric hindrance.
- Copper-Free Click Chemistry: BCN group supports copper-free SPAAC, suitable for sensitive applications.
Applications:
- Protein Modification: Allows proteins to be attached to surfaces or other molecules.
- Bioconjugation: Useful for linking biomolecules in research and therapeutic development.
- Antibody-Drug Conjugates (ADCs): Acts as a linker in ADC synthesis for targeted drug delivery.
Storage:
Store according to recommended conditions to maintain stability and reactivity.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
