Ald-benzoylamide-PEG4-CH2 NHS ester
This high-purity heterobifunctional PEG linker has a terminal aldehyde for oxime or hydrazone ligation and an NHS ester specifically for amine coupling. The PEG4 spacer improves solubility, flexibility, and reduces steric hindrance for efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Aldehyde Group – Reacts selectively with aminooxy and hydrazide groups to form stable oxime or hydrazone bonds.
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NHS Ester – Couples efficiently to primary amines on proteins, peptides, and other biomolecules.
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PEG4 Spacer – Improves solubility, flexibility, and accessibility of reactive groups.
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Orthogonal Reactivity – Enables sequential, site-specific conjugations without cross-reactivity.
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High Purity – Supplied at >95% purity for consistent, reproducible results.
Applications
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Dual-functional linker for orthogonal bioconjugation
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Protein, peptide, and glycan modification
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Multifunctional probe and diagnostic agent synthesis
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Antibody–drug conjugate (ADC) linker chemistry
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged moisture exposure to preserve reactivity
This product combines aldehyde-based oxime/hydrazone ligation with efficient amine coupling via NHS ester, connected by a PEG4 spacer for solubility and flexibility, making it especially ideal for precise, orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
