Thalidomide-O-PEG4-Propargyl
This product is a PEG linker containing a thalidomide derivative, a PEG4 spacer, and a terminal propargyl group. It enables cereblon E3 ligase recruitment and copper-catalyzed or copper-free click chemistry, making it especially valuable in PROTAC and bioconjugation research.
Key Features and Benefits
-
Thalidomide Moiety: Functions as a cereblon-binding ligand for targeted protein degradation.
-
Propargyl Group: Supports CuAAC or SPAAC click chemistry with azides.
-
PEG4 Spacer: Provides solubility and flexible molecular spacing.
-
Dual Reactivity: Combines cereblon recruitment with click chemistry.
-
High Purity: Ensures reproducible performance in medicinal chemistry workflows.
Applications
-
PROTAC Development: Serves as a cereblon ligand with click compatibility.
-
Bioconjugation: Links thalidomide-based ligands with azide-modified biomolecules.
-
Probe Development: Builds multifunctional probes for protein degradation studies.
-
Drug Discovery: Provides a modular scaffold for therapeutic conjugates.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates cereblon recruitment with alkyne click reactivity in a PEG4 scaffold, providing an especially versatile tool for targeted protein degradation research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
