Propargyl-PEG1-acid
This product is a compact heterobifunctional linker containing a terminal propargyl (alkyne) group, a short PEG1 spacer, and a carboxylic acid. The alkyne supports copper-catalyzed (CuAAC) or copper-free click chemistry with azides, while the carboxyl group couples efficiently with amines or activated esters. Its short PEG1 spacer provides minimal length while improving hydrophilicity, making this reagent ideal for compact conjugation strategies.
Key Features and Benefits
-
Propargyl Group: Enables CuAAC or SPAAC click chemistry with azides.
-
Carboxylic Acid Group: Couples readily with amines to form stable amide bonds.
-
PEG1 Spacer: Provides solubility and flexibility in a compact scaffold.
-
Dual Reactivity: Supports orthogonal click chemistry and amine coupling.
-
High Purity: Produced to ≥95% purity for reproducibility.
Applications
-
Bioconjugation: Links azide- and amine-bearing biomolecules.
-
Protein and Antibody Labeling: Adds orthogonal reactive handles for site-specific modification.
-
Probe Development: Builds compact, multifunctional probes for imaging and diagnostics.
-
Drug Delivery: Functions as a short PEG linker in therapeutic systems.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, desiccated container.
-
Handling: Prepare fresh solutions; avoid repeated freeze–thaw cycles.
This product combines alkyne click chemistry with amine-reactive carboxyl functionality in a short PEG scaffold, specifically offering an efficient tool for compact conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
