NH-bis(PEG4-t-butyl ester)
This product is a multifunctional PEG reagent containing a central amine core substituted with two PEG4 chains, each terminated in a t-butyl ester protecting group. This design provides solubility, orthogonal protection, and extended spacing, making it especially effective for bioconjugation, drug delivery, and synthetic chemistry.
Key Features and Benefits:
-
Central Amine Core: Serves as a branching scaffold for dual PEG arms.
-
t-Butyl Esters: Provide acid-labile protection for controlled deprotection.
-
PEG4 Chains: Enhance solubility, flexibility, and steric accessibility.
-
Orthogonal Design: Supports stepwise, multifunctional synthesis strategies.
-
High Purity: Ensures reliable and reproducible results.
Applications:
-
Bioconjugation: Builds multifunctional PEGylated conjugates with protected handles.
-
Drug Delivery: Provides PEGylated scaffolds with controlled release strategies.
-
Probe Development: Serves as a protected intermediate in diagnostic probe design.
-
Synthetic Chemistry: Useful in orthogonal linker and polymer synthesis.
Storage and Handling:
-
Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature ester cleavage.
This product combines a branching PEG scaffold with acid-labile esters, specifically offering solubility, orthogonal control, and versatility for advanced bioconjugation and synthetic workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
