NH-bis(PEG2-t-butyl ester)
This product is a multifunctional PEG-based linker with a central amine core and two PEG2 arms terminated in t-butyl esters. The PEG2 chains provide hydrophilicity and flexibility, while the t-butyl esters serve as acid-labile protecting groups for controlled deprotection and orthogonal conjugation strategies.
Key Features and Benefits:
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Dual t-Butyl Esters: Acid-labile protection for controlled release of carboxyl groups.
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Amine Core: Provides a branching scaffold for multifunctional design.
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PEG2 Arms: Add solubility, flexibility, and reduced steric hindrance.
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High Purity: Ensures reproducibility in synthetic and bioconjugation workflows.
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Orthogonal Reactivity: Supports stepwise, multifunctional synthesis strategies.
Applications:
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Bioconjugation: Enables controlled dual carboxyl release for biomolecule attachment.
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Drug Delivery: PEGylated scaffold improves solubility and stability with tunable release.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, and polymers with dual handles.
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Synthetic Chemistry: Intermediate for constructing branched or multifunctional PEG scaffolds.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve ester stability until deprotection.
This product offers dual acid-labile esters on a PEGylated amine scaffold, making it an especially versatile reagent for orthogonal synthesis, bioconjugation, and advanced material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
