Ms-PEG4-t-butyl ester
This product is a PEG linker containing a mesyl (methanesulfonyl) group, a PEG4 spacer, and a tert-butyl ester. It specifically enables nucleophilic substitution through the mesyl group and provides a protected carboxyl group for staged conjugation.
Key Features and Benefits
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Mesyl Group: Functions as an excellent leaving group for nucleophilic substitution.
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t-Butyl Ester: Protects the carboxyl group for controlled deprotection.
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PEG4 Spacer: Improves solubility and provides moderate chain length.
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Dual Reactivity: Combines mesyl substitution with protected carboxyl functionality.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications
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Organic Synthesis: Serves as an intermediate for custom PEG derivatives.
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Bioconjugation: Provides scaffolds with substitution and protected carboxyl reactivity.
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Probe Development: Builds dual-reactive probes for imaging and diagnostics.
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Drug Delivery: Delivers PEG scaffolds with solubility and orthogonal chemistry.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis.
This product integrates mesyl leaving group chemistry with a protected acid handle in a PEG4 scaffold, specifically offering flexible synthetic reactivity.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
