TCO-PNB Ester
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group for ultrafast tetrazine ligation and a para-nitrobenzyl (PNB) ester as a cleavable protecting group. This combination provides bioorthogonal reactivity and controlled release, making it especially ideal for drug delivery, probe design, and advanced bioconjugation.
Key Features and Benefits:
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TCO Group: Enables rapid, copper-free IEDDA click chemistry with tetrazines.
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PNB Ester: Provides acid- or reductive-labile protection for controlled release.
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Orthogonal Reactivity: Supports stepwise and multifunctional conjugation.
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Compact Design: Facilitates efficient reactions with minimal steric hindrance.
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High Purity: Ensures reliable performance in sensitive workflows.
Applications:
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Drug Delivery: Provides cleavable linkers for targeted therapeutic release.
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Probe Development: Builds bioorthogonal probes for imaging and diagnostics.
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Bioconjugation: Links biomolecules via TCO click chemistry with controlled deprotection.
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Synthetic Chemistry: Serves as a versatile intermediate for multifunctional linkers.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); protect TCO from prolonged light exposure.
This product combines ultrafast TCO click chemistry with a cleavable ester, specifically offering both reactivity and controlled release for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.