Bis-Mal-PEG3
This product is a homobifunctional linker containing two maleimide groups connected by a short PEG3 spacer. The maleimide moieties react selectively with thiols to form stable thioether bonds, while the PEG3 chain improves solubility and provides flexibility. This compact, thiol-reactive crosslinker is especially used in protein modification, ADC development, and polymer crosslinking.
Key Features and Benefits
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Dual Maleimide Groups: Enable efficient and selective thiol conjugation.
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PEG3 Spacer: Adds hydrophilicity and reduces steric hindrance.
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Homobifunctional Design: Facilitates crosslinking of two thiol-containing molecules.
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Compact Structure: Provides short, stable spacing between conjugated partners.
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High Purity: Produced to ≥95% purity for reproducible results.
Applications
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Protein Crosslinking: Links cysteine residues in proteins and antibodies.
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Antibody–Drug Conjugates (ADCs): Serves as a thiol-reactive linker for payload attachment.
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Polymer Modification: Crosslinks thiol-containing polymers and hydrogels.
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Probe Development: Builds multifunctional probes through thiol–maleimide chemistry.
Storage and Handling
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Storage: Store at –20 °C in a tightly sealed, light- and moisture-protected container.
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Handling: Use freshly prepared solutions; avoid prolonged exposure to aqueous buffers.
This product combines dual maleimide reactivity with PEG solubility in a short spacer, making it an especially excellent tool for crosslinking, bioconjugation, and therapeutic research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
