Bis-Mal-PEG7 provides a homobifunctional PEG linker with two terminal maleimide groups connected through a hydrophilic PEG7 spacer, while its dual thiol-reactive functionality supports crosslinking, bioconjugation, protein modification, and functional biomaterial research.
Key Features and Benefits
- Homobifunctional Linker: Provides two maleimide groups for linking thiol-containing molecules through a PEG7 spacer.
- Dual Maleimide Functionality: Two terminal maleimide groups specifically enable thiol-selective conjugation at both ends of the linker.
- PEG7 Spacer: Provides a flexible, hydrophilic spacer that specifically separates conjugated molecules and supports molecular accessibility.
- Thiol-Reactive Chemistry: Maleimide groups react efficiently with free sulfhydryl groups under suitable reaction conditions.
- Stable Thioether Formation: Maleimide-thiol reactions form covalent thioether linkages for molecular conjugation and crosslinking.
- Molecular Crosslinking: Dual reactive ends specifically support covalent linkage of two thiol-containing molecules or materials.
- Hydrophilic Linker Design: The PEG7 spacer adds hydrophilic character and flexible spacing between conjugated components.
- Versatile Conjugation Platform: Supports modification of proteins, peptides, polymers, nanoparticles, and other thiol-containing research materials.
Applications
- Bioconjugation: Supports covalent linkage of compatible thiol-containing biomolecules and functional components.
- Thiol Conjugation: Dual maleimide groups specifically enable selective coupling with accessible sulfhydryl groups.
- Protein Crosslinking: Useful for linking proteins containing naturally occurring or introduced cysteine residues.
- Peptide Conjugation: Supports crosslinking and functionalization of cysteine-containing peptides.
- Molecular Crosslinking: Connects two compatible thiol-bearing molecules through a hydrophilic PEG7 spacer.
- Polymer Functionalization: Supports incorporation of thiol-containing molecules into appropriately designed polymer systems.
- Nanoparticle Functionalization: Enables crosslinking and surface modification of compatible thiol-functionalized nanoparticles.
- Biomaterial Research: Supports development of functional materials using maleimide-thiol conjugation chemistry.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize prolonged aqueous exposure to reduce maleimide hydrolysis.
Bis-Mal-PEG7 combines two thiol-reactive maleimide groups with a flexible PEG7 spacer, while its homobifunctional architecture supports crosslinking, bioconjugation, protein modification, and functional material development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
