Mal-PEG5-acid
This product is a heterobifunctional PEG linker containing a maleimide group and a terminal carboxylic acid, separated by a PEG5 spacer. It specifically enables thiol–maleimide conjugation and amide coupling, offering solubility, flexibility, and efficient bioconjugation capacity.
Key Features and Benefits
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Dual Functional Groups: Maleimide for thiol-specific conjugation; carboxylic acid for amide bond formation.
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PEG5 Spacer: Improves solubility and provides moderate, flexible spacing.
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High Selectivity: Maleimide reacts specifically with sulfhydryl groups.
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Versatile Linker: Supports crosslinking, multifunctional conjugation, and drug delivery strategies.
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High Purity: Ensures reproducibility and consistency in sensitive workflows.
Applications
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Bioconjugation: Couples thiol- and amine-containing biomolecules through orthogonal groups.
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Drug Delivery: Provides PEG scaffolds for targeted conjugates.
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Diagnostics: Functionalizes biomolecules for imaging and assay development.
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Protein Engineering: Attaches PEG or functional tags to cysteine residues.
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Organic Synthesis: Serves as an intermediate for linker and scaffold design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates a thiol-reactive maleimide and a carboxylic acid group across a PEG5 spacer, specifically providing solubility, flexibility, and orthogonal reactivity for bioconjugation and pharmaceutical applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
