DBCO-C3-PEG4-NH-Boc
This product is a bifunctional PEG linker containing a dibenzocyclooctyne (DBCO) group, a PEG4 spacer with a C3 extension, and a Boc-protected amine. It specifically supports copper-free click chemistry with azides and provides an orthogonal protected amine for selective conjugation.
Key Features and Benefits
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DBCO Group: Enables strain-promoted azide–alkyne cycloaddition (SPAAC) without copper.
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PEG4-C3 Spacer: Improves solubility and provides flexible spacing.
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Boc-Protected Amine: Allows controlled deprotection for orthogonal amine conjugation.
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Dual Reactivity: Combines bioorthogonal click chemistry with protected amine functionality.
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High Purity: Ensures reproducibility in advanced bioconjugation workflows.
Applications
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Bioconjugation: Couples azide-modified biomolecules and amine-reactive partners.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Constructs PEGylated scaffolds with orthogonal reactivity.
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Material Science: Functionalizes polymers and nanoparticles with dual handles.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO to preserve reactivity.
This product integrates DBCO click reactivity with a Boc-protected amine in a PEG4-C3 scaffold, specifically offering a versatile tool for multifunctional conjugation and linker design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
