SPDP-PEG8-acid
This product is a heterobifunctional linker featuring an SPDP (succinimidyl 3-(2-pyridyldithio)propionate) group for thiol-reactive conjugation and a terminal carboxylic acid for amide coupling. The PEG8 spacer improves solubility, flexibility, and spacing, making this reagent especially effective for bioconjugation, cleavable linker design, and drug delivery.
Key Features and Benefits:
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SPDP Group: Reacts selectively with thiols and provides disulfide-cleavable linkage.
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Carboxylic Acid: Couples efficiently with primary amines via amide bond formation.
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PEG8 Spacer: Enhances solubility, hydrophilicity, and steric accessibility.
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Cleavable Design: Enables redox-sensitive release in bioconjugates.
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High Purity: Ensures reproducibility in advanced workflows.
Applications:
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Bioconjugation: Links thiol- and amine-containing biomolecules with cleavable control.
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ADC Development: Builds redox-sensitive antibody–drug conjugates.
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Probe Development: Constructs cleavable imaging or diagnostic probes.
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Drug Delivery: Supports PEGylated, redox-sensitive conjugation strategies.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); protect from reducing agents to preserve SPDP activity.
This product combines a thiol-reactive, cleavable SPDP group with a carboxylic acid handle in a PEG8 scaffold, specifically offering versatility in probe development, drug delivery, and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
