TCO-PEG5-BCN
This product is a heterobifunctional linker containing a trans-cyclooctene (TCO) for ultrafast tetrazine ligation and a bicyclononyne (BCN) for copper-free SPAAC click chemistry. The PEG5 spacer provides solubility, flexibility, and spacing, making this dual-reactive linker especially ideal for multifunctional bioconjugation, probe design, and therapeutic development.
Key Features and Benefits:
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TCO Group: Enables rapid, catalyst-free IEDDA reactions with tetrazines.
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BCN Group: Supports SPAAC click chemistry with azides.
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PEG5 Spacer: Improves solubility, hydrophilicity, and steric accessibility.
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Dual Reactivity: Combines two orthogonal click handles in one scaffold.
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High Purity: Ensures reproducibility in advanced bioconjugation workflows.
Applications:
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Bioorthogonal Labeling: Enables dual orthogonal conjugation strategies in vitro and in vivo.
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ADC Development: Useful in designing multifunctional antibody–drug conjugates.
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Probe Development: Builds dual-functional probes for imaging or diagnostics.
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Drug Delivery: Provides flexible PEGylated design for targeted conjugation.
Storage and Handling:
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Storage: Store at –20 °C in a moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); protect TCO from light to preserve reactivity.
This product integrates two powerful click handles with PEG-enhanced solubility, making it an especially versatile dual-functional linker for advanced bioconjugation and therapeutic research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
