endo-BCN-PEG2-amine
endo-BCN-PEG2-amine is a high-purity heterobifunctional linker with an endo-bicyclo[6.1.0]non-4-yne (endo-BCN) for rapid, copper-free SPAAC click chemistry and a primary amine for efficient coupling with carboxylic acids or activated esters. The PEG2 spacer specifically enhances solubility, flexibility, and reduces steric hindrance, enabling high-yield conjugations in aqueous and organic systems. This reagent is especially ideal for bioorthogonal labeling, site-specific modification, and nanoparticle functionalization.
Key Features and Benefits
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Endo-BCN Group: Enables fast, catalyst-free SPAAC click chemistry with azides.
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Primary Amine: Forms stable amide bonds with carboxyl or NHS ester groups.
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PEG2 Spacer: Improves solubility and molecular flexibility for efficient conjugation.
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Heterobifunctional Design: Supports orthogonal, site-specific modifications.
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High Purity: Supplied at >95% purity for reliable performance.
Applications
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Copper-free bioorthogonal labeling of azide-functionalized biomolecules.
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Protein, peptide, and small molecule conjugation.
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Nanoparticle and surface functionalization.
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Development of targeted drug delivery systems.
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Site-specific labeling in imaging and diagnostic assays.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to maintain reactivity.
This product offers copper-free click chemistry via BCN and amine coupling through a PEG2 spacer, specifically providing solubility and flexibility for bioconjugation and material functionalization.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
