Bromo-PEG2-CH2CO2tBu
This product is a heterobifunctional PEG2 linker with a terminal bromo group and a tert-butyl ester–protected carboxymethyl group. The PEG2 spacer improves solubility and flexibility, while the bromo group specifically enables nucleophilic substitution and the tBu ester provides acid-labile protection for orthogonal conjugation.
Key Features and Benefits:
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Bromo Group: Reactive alkyl halide for substitution with nucleophiles (amines, thiols, etc.).
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tBu-Protected Carboxyl: Acid-labile ester for controlled deprotection and amide formation.
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PEG2 Spacer: Short, flexible, and hydrophilic chain reducing steric hindrance.
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High Purity: Ensures reproducibility in bioconjugation and synthetic chemistry.
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Orthogonal Reactivity: Combines halide substitution with protected acid chemistry.
Applications:
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Bioconjugation: Precise linker for introducing PEG spacing in biomolecules.
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Drug Delivery: PEGylated scaffold to enhance solubility and pharmacokinetics.
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Surface Modification: Functionalizes nanoparticles, hydrogels, and polymers.
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Synthetic Chemistry: Intermediate for orthogonal stepwise conjugation strategies.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO, acetonitrile) to maintain bromo and ester stability.
This product offers halide reactivity combined with an acid-labile tBu ester, making it an especially versatile short PEG linker for orthogonal conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
