Alloc-Val-Ala-PAB-OH
This product is a cleavable linker containing an allyloxycarbonyl (Alloc) protecting group, a Val-Ala dipeptide, and a p-aminobenzyl (PAB) spacer with a free hydroxyl terminus. The Val-Ala sequence is recognized and cleaved by lysosomal proteases such as cathepsins, while the PAB spacer undergoes self-immolative cleavage for efficient payload release. The Alloc group provides orthogonal protection, specifically allowing controlled deprotection in synthetic workflows.
Key Features and Benefits
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Alloc Group: Provides orthogonal protection, enabling stepwise synthesis.
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Val-Ala Dipeptide: Cleaved by proteases like cathepsins for controlled release.
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PAB Spacer: Ensures efficient self-immolative payload liberation.
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Hydroxyl Group: Serves as a modifiable handle for conjugation.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Antibody–Drug Conjugates (ADCs): Functions as a protease-cleavable linker.
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Drug Delivery: Enables selective intracellular release of therapeutics.
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Probe Development: Creates cleavable probes for imaging and diagnostics.
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Medicinal Chemistry: Serves as a modular building block.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Use under inert conditions when possible; avoid prolonged exposure to moisture.
This product integrates protease cleavability, self-immolative release, and orthogonal protection, making it an especially versatile linker for drug delivery and ADC design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
