Boc-Val-Ala-PAB-PNP, CAS: 1884578-00-0, is a cleavable linker in drug conjugates and bioconjugation applications. It contains a tert-butoxycarbonyl group for temporary N-terminal protection, a Val-Ala dipeptide sequence, and a para-aminobenzyl-p-nitrophenol linker, which can be enzymatically or chemically cleaved to release the active payload.
Key Features:
- Boc Protection: Shields the N-terminal amine during synthesis, allowing for stepwise conjugation.
- Val-Ala Dipeptide: Acts as a cleavable linker, often sensitive to specific enzymes in targeted drug release.
- PAB-PNP Linker: Enables controlled release of active molecules upon cleavage, commonly used in drug delivery systems.
Applications:
- Drug Conjugates: Used in antibody-drug conjugates (ADCs) and prodrugs for targeted delivery.
- Bioconjugation: Facilitates linking of therapeutic agents to biomolecules, allowing for controlled activation and release.
- Protein and Peptide Modification: Adds temporary protection and targeted release mechanisms in biochemical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
