TCO-carbonylamino-benzamido-PEG3 acid
This product is a heterobifunctional linker featuring a trans-cyclooctene (TCO) group, a benzamido unit, a PEG3 spacer, and a terminal carboxylic acid. The TCO enables ultrafast, copper-free click chemistry with tetrazines via IEDDA ligation, while the carboxyl group couples efficiently with amines or activated esters. The PEG3 chain specifically provides solubility and moderate spacing, making this reagent valuable for bioconjugation, probe development, and drug delivery.
Key Features and Benefits
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TCO Group: Supports ultrafast, copper-free click ligation with tetrazines.
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Carboxylic Acid Group: Couples efficiently with amines to form stable amide bonds.
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PEG3 Spacer: Improves solubility and reduces steric hindrance.
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Balanced Design: Compact yet flexible structure for versatile conjugation.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Links TCO-modified biomolecules with amine-bearing partners.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Serves as a linker for targeted therapeutic systems.
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Synthetic Chemistry: Functions as a modular building block in advanced synthesis.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Prepare fresh solutions before use; avoid repeated freeze–thaw cycles.
This product combines ultrafast click reactivity with amine-coupling functionality in a compact PEG scaffold, specifically offering a reliable tool for controlled bioconjugation and therapeutic development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
